Centre for Molecular and Biomolecular Informatics
Radboud University Nijmegen
|Introduction to Retrosynthetic Analysis|
Chemical reactions can be viewed in two directions: the synthetic direction, corresponding to laboratory operations, and the retrosynthetic (or antithetic) direction, going backwards from a target molecule to starting materials by way of retro-reactions or transforms. Retrosynthesis is often applied when a synthetic route to a target molecule has to be developed. The term retrosynthetic analysis, a synonym for retrosynthesis, expresses more clearly its `imaginary' character.
The most important computer programs for synthesis design (a prime example is LHASA) operate in a retrosynthetic fashion. The reason for this is that retrosynthetic analysis lends itself well to a description in algorithms and thence in computer programs.
The following chapters provide an overview of retrosynthetic analysis:
|Page author: Martin Ott||Last update: Wednesday, 1 September 2004|