Centre for Molecular and Biomolecular Informatics
Radboud University Nijmegen
The program suite SYBYL consists of a number of computational chemistry modules to describe and predict molecular behaviour.
The Basic module performs the task of reading or sketching structures and initiating minimisations. It is menu-driven, giving access to over 200 fragments, and offers minimisation at different levels of sophistication. The Advanced Computation module performs conformational analysis, comparison, volume and map calculations, etc. The Biopolymer module offers a smooth and intuitive guide for protein and nucleic acid modelling problems. Composer provides the user with tools for knowledge-based homology modelling of protein structures. The QSAR/CoMFA module comprises advanced tools for generating and manipulating tables, the so-called Molecular Spreadsheets, and comparing molecules based on their steric and electrostatic fields.
SYBYL is the main modelling package of the Centre.
The program can be used on any X-terminal
connected to the Internet network, allowing a connection from
the user's X-window to CMBI's main server machine.
Interfaces to the Protein Databank (PDB), Cambridge Structural Database (CSD), and various semi-empirical programs such as MOPAC are provided.
|A typical display from a SYBYL session, featuring a small part of a B-DNA model.|
|Click on image for full display|
On-line documentation (available for registered users only):
A number of basic tutorials are also available on-line.
See also Tripos' SYBYL page.
1699 South Hanley Road
St. Louis, MO 63144
SYBYL courses can be arranged with CMBI on request.
|Page author: Martin Ott||Last update: Tuesday, 9 November 2004|